Myeloproliferative Disorders Essay Example | Topics and Well Written Essays - 1250 words

Myeloproliferative Disorders - Essay Example In 2005, similarity in the major disease groups of MPDs got some explanation when Janus Kinase 2 V617F (JAK2- V617F) which in fact represents a G to T somatic mutation of JAK2 at nucleotide 1849, in exon 14, which eventually end up in the substitution of valine to phenylalanine at codon 617 (Tefferi 2006). Apparently, it seems that all group members of MPDs contain JAK2-V617F in equal proportion in all patients, persistently; which raises the question of capturing all disorders in the group through a single mutation, how is it possible But this is not the case! In fact, various diseases of the group carry this mutation in their genetic materials with different proportions in different patients; moreover, these diseases do not constantly carry this mutation as a universal principle. ... Various researchers have got the evidence to describe that the proportion of the patients with one of the three diseases of MPDs carry JAK2-V617F in different proportions and among these diseases PV is the disease which carries it to the maximum level. According to Tefferi (Tefferi 2006), almost all patients with PV carry the mutation while in the remaining two diseases, ET and IM, about half of the patients each in the two groups carry JAK2-V617F. While Jones et al (Jones 2005) gave could capture lower frequency of the mutation in these diseases, like: 81 percent of the patients with PV could show JAK2-V617F, 43 percent with IM and 41 percent with ET were able to reflect the mutated genetic material. This non-consistent behaviour of the mutated genetic material demands some further exploration in this area. One possible explanation in the favour of single mutation with multiple diseases still exists and which is related to sensitivity and specificity of the tests capturing the findings, which support JAK2-V617F. There are chances that mutation is present in the disease groups belonging to MPDs but the available tests are not efficient enough to detect that. For this answer we need to wait for the availability of refined testing system. At the same time it seems obvious that some other mechanisms are also operating in differentiating the progenitor to different diseases. Whether these mechanisms are timed before, after or at the same time as the mutation develops; it is to be answered. Jamieson et al (Jamieson 2006) found through their study that: in samples of PV patients, the cells with haematopoietic stem cells phenotype produced JAK2-V617F which in

DQ knolege creathion Essay Example | Topics and Well Written Essays - 1000 words

DQ knolege creathion - Essay Example Can be linked to the work place where it is to be implemented. 4. Solutions to be implemented are found to be efficient in both time taken and overall cost.. It is those who make decisions within an organization who can best take advantage of any research results as this should serve to highlight such things as current and future market trends as well as any possible risks to be considered The maximum benefit from any research undertaken will be achieved if it is based upon most accurate picture of what is actually happening as well as the theories involved, but it can prove to be a difficult task to fit the practical results alongside the theoretical models. The aim for business researchers must be to arrive at knowledge based upon the two complementary aspects of rigour and usefulness. Rousseau ( 2006) and other proponents of a management style based upon evidence believe that this is possible. However , more recently Morrell ( 2008) criticized this picture and questioned whether i t was really possible for management research to be done in this way and yet be rigorous enough. Is such research valid or is it just based upon theories? The topic for research, if it is to serve a useful purpose, must come out of the workplace ad problems faced there Such an example occurred when I worked for KPC Kuwait petroleum. Each month a crude monthly price was issued according to a fixed discount on the Saudi AM price for their crude. This real life practice example was afterwards used as a topic by management researchers. In 2009 Kieser & Leiner said that they thought that it should be easy for practice and theory to come together because good research can unite theory and the practice. For this reason education , whether in business schools or a mainstream university, is able to provide management researchers with the skills necessary to cope with any problems which arise. In 1987, Shrivastava (, p 88) suggested the use of research variables in relation to the goals of an organization and that research findings must be tested in situ with researchers being rewarded , testing research findings in organisational settings and reward researchers based upon the way in which their research can be applied in a practical way. In this way the gap often observed between practice and research will be closed or at shrink to a smaller one., as echoed ( 2005) by Bennis and O’Toole. It was suggested by Rousseau ( 2006, page 266) that the best evidence based research should be linked to work practise and solutions arrived at using a process of cause and effect. The culture of an organization that wants to be successful must allow for intelligent experimentation and possible failure in order the useful knowledge can be created. Rousseau believes that management is such a complex field that metaskills are required to deal with it successfully. Over simplification is a danger to be avoided, because there are no ‘one size fits all’ answers ( page 26 7) Also suggested by the same author is that feedback must flow with ease between educators, managers and researchers. On page 257 ( 2006) decries management gurus such as Jack Welsh and McKinsey who seem to suggest management decisions based upon relatively weak evidence. On the other hand their suggestions are relatively easy to understand as compared to duller and complex academic offerings. Perhaps there needs to be a middle way such as the 2005 article by Bennis and O’Toole in Harvard Business Review, which is a non-academic, non peer reviewed